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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGCS1
All Species:
26.59
Human Site:
S516
Identified Species:
39
UniProt:
Q01581
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q01581
NP_001091742.1
520
57294
S516
E
P
E
A
A
V
I
S
N
G
E
H
_
_
_
Chimpanzee
Pan troglodytes
XP_517780
610
66491
S606
E
P
E
A
A
V
I
S
N
G
E
H
_
_
_
Rhesus Macaque
Macaca mulatta
XP_001090857
592
65050
S588
E
P
E
A
A
V
I
S
N
G
E
H
_
_
_
Dog
Lupus familis
XP_536483
637
69021
S633
E
A
E
A
A
V
I
S
N
G
E
H
_
_
_
Cat
Felis silvestris
Mouse
Mus musculus
Q8JZK9
520
57550
S516
E
S
E
S
A
V
I
S
N
G
E
H
_
_
_
Rat
Rattus norvegicus
P17425
520
57415
S516
E
P
E
S
A
V
I
S
N
G
E
H
_
_
_
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506375
520
57160
Chicken
Gallus gallus
P23228
522
57541
I517
S
E
G
V
T
V
A
I
S
N
G
V
H
_
_
Frog
Xenopus laevis
NP_001087380
520
57303
Zebra Danio
Brachydanio rerio
NP_957379
508
55918
S504
G
P
E
V
V
V
M
S
N
G
D
H
_
_
_
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524711
465
51158
Honey Bee
Apis mellifera
XP_397202
453
50855
Nematode Worm
Caenorhab. elegans
P54871
462
51397
Sea Urchin
Strong. purpuratus
XP_801879
508
56054
T501
K
S
V
E
D
M
E
T
A
E
Q
V
T
V
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P54873
461
51076
Baker's Yeast
Sacchar. cerevisiae
P54839
491
54995
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85
87.3
78.6
N.A.
94.6
94.8
N.A.
90.1
83.9
80
77.6
N.A.
58
54.6
38.4
63.2
Protein Similarity:
100
85
87.3
80.5
N.A.
97.5
97.6
N.A.
95.3
91
88.6
87.1
N.A.
69.6
68.6
54.8
75.3
P-Site Identity:
100
100
100
91.6
N.A.
83.3
91.6
N.A.
0
7.6
0
58.3
N.A.
0
0
0
0
P-Site Similarity:
100
100
100
91.6
N.A.
91.6
100
N.A.
0
15.3
0
75
N.A.
0
0
0
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
44
45.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
60.1
60.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
25
38
0
7
0
7
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
7
0
0
0
0
0
7
0
0
0
0
% D
% Glu:
38
7
44
7
0
0
7
0
0
7
38
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
7
0
7
0
0
0
0
0
0
44
7
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
44
7
0
0
% H
% Ile:
0
0
0
0
0
0
38
7
0
0
0
0
0
0
0
% I
% Lys:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
7
7
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
44
7
0
0
0
0
0
% N
% Pro:
0
32
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
7
13
0
13
0
0
0
44
7
0
0
0
0
0
7
% S
% Thr:
0
0
0
0
7
0
0
7
0
0
0
0
7
0
0
% T
% Val:
0
0
7
13
7
50
0
0
0
0
0
13
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
44
50
50
% _